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GRK 2624
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Research
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Projects
I7: SparcePolygenMods
regularised regression such as the Lasso ( snpnet , Qian et al., 2020) and statistical boosting approaches ( snpboost , Klinkhammer et al., 2023), providing SNP selection via L1-regularization and early stopping [...] > 200,000 subjects) and the number of common SNPs potentially included in the PRS models (e.g., p > 1,000,000 SNPs). While univariate effect estimates, publicly available as summary statistics from genome-wide [...] variants discovered from diverse populations improves polygenic risk score transferability. HGG Adv, 2(1), 100017. doi: 10.1016/j.xhgg.2020.100017 Dudbridge F (2021). Polygenic Mendelian randomization. Cold …