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Microsoft Word - Prachayasittikul_thiotetrahydropyridine_proof_060509.doc
(CO) cm-1; UV(95 % ethanol)λmax nm (logε): 202 (4.33), 243 (4.07); 1H-NMR (300 MHz, CDCl3): δ6.12 (d, J = 4.1 Hz, 1H, H-5), 5.95 (d, J = 4.1 Hz, 1H, H-6), 5.64 (d, J = 1.2 Hz, 1H, H-2), 3.95 (d, J = 1.2 Hz [...] phenyl)-1,2,3,4-tetrahydro- pyridines (15a-b), 1-acetyl-2-(1-adaman-
tylthio)-3-hydroxy-3-methyl-4-acetoxy- 1,2,3,4-tetrahydropyridine (16), 1-acetyl-2- (1-adamantylthio)-3-acetoxy-4-phenyl-6- hydroxy-1,2,3 [...] isomeric forms; 1,2,3,6-, 1,2,3,4- and 2,3,4,5-tetrahydro- pyridines. 1-Methyl-4-phenyl–1,2,3,6–tetra- hydropyridines (1) is a potent neurotoxin in dopaminergic system. Tetrahydropyridine 1 was a byproduct …